In order to function effectively, the Commission needs to organize and prepare its work carefully and in advance. Such tasks are carried out by the Bureau and the Extended Bureau of the Commission, which play an active role in the preparation of the regular and the inter-sessional meetings with the assistance of the Secretariat.
The Bureau of the Commission is composed of the Chairperson, three Vice-Chairpersons and one Rapporteur. At the end of its reconvened session, the Commission elects its Bureau for the next session. The Extended Bureau also includes the Chairpersons of the five regional groups, the European Union and the Group of 77 and China.
The Commission is composed of 40 Member States elected by the Economic and Social Council, with the following distribution of seats among the regional groups:
(a) Twelve for African States;
(b) Nine for Asian States;
(c) Eight for Latin American and Caribbean States;
(d) Four for Eastern European States;
(e) Seven for Western European and other States.
The term of office for Commission Members is three years.
H.E. Ambassador Ruediger BOHN of Germany (Group of Western European and Other States)
H.E. Ambassador Atsushi KAIFU of Japan (Group of Asia-Pacific States)
H.E. Ambassador Mohammed NASR of Egypt (African Group)
H.E. Ambassador Eglantina GJERMENI of Albania (Group of Eastern European States)
Ms. Sussely Anaite Sanchez MiRANDA, Counsellor of the Permanent Mission of Guatemala (Group of Latin American and Caribbean States)

| As of July 2024 | Permanent/Resident Representative of the Federal Republic of Germany to the Office of the United Nations and to other International Organizations, Vienna |
| 2022-2024 | Deputy Head of Mission, German Embassy London |
| 2018-2022 | Commissioner for Non-proliferation, Disarmament and Arms Control, Ambassador, German MFA |
| 2017-2018 | Head of Division Security Policy, Non-proliferation and Arms Control; Bilateral Relations with the USA, Canada, North, West and South Europe as well as Turkey at the Federal Chancellery, Berlin |
| 2016-2017 | Division for Conventional Arms Control and CSBM, German MFA |
| 2015-2016 | Political Section of the German Embassy in Washington DC |
| 2013-2015 | German Embassy in Washington DC, Director of the “German Information Center” |
| 2010-2013 | Division for organizational affairs and resource allocation, German MFA |
| 2009-2010 | Hertie-School of Governance, Berlin |
| 2006-2009 | German Embassy Tashkent, Uzbekistan, Deputy Head of Mission |
| 2003-2006 | German NATO Delegation, Brussels |
| 2000-2003 | Personnel Department, German MFA |
| 1999-2000 | Kennedy School of Government, Harvard University |
| 1996-1999 | German Embassy Amman, Jordan |
| 1994-1996 | Economic Department, German MFA |
| 1992-1994 | Attaché at the Diplomatic Academy, German MFA |
| 1987-1992 | Arabic studies and int. Law at Leipzig University |